.search-filter {
    margin-bottom: 15px;
    display: flex;
    gap: 15px;
    flex-wrap: wrap;
    align-items: center;
  }
  .search-box {
    flex: 1;
    min-width: 300px;
    position: relative;
  }
  .search-box input {
    width: 100%!important;
    padding:15px 30px 15px 20px!important;
    border: 2px solid #e0e0e0!important;
    border-radius: 30px!important;
    font-size: 14px!important;
    transition: border-color 0.3s ease!important;
  }
  .search-box input:focus {
    outline: none!important;
    border-color: #0d3320!important;
  }
  .filter-buttons {
    display: flex;
    gap: 10px;
    flex-wrap: wrap;
  }
  .filter-btn {
    padding: 10px 20px;
    border: 2px solid #667eea;
    background: white;
    color: #667eea;
    border-radius: 20px;
    cursor: pointer;
    transition: all 0.3s ease-out;
    font-weight: 500;
    font-size: 0.9rem;
  }
  .filter-btn:hover,
  .filter-btn.active {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    color: white;
  }
  .category {
    overflow: hidden;
    transition: all 0.3s ease-out;
    backdrop-filter: brightness(102%) blur(30px);
    background-color: #fff0;
    border-radius: 15px;
    margin-bottom: 20px;
  }
  .category:hover {
    border-color: #000;
  }
  .category-header {
    color: #0d3320;
    padding: 12px 25px;
    font-size: 20px!important;
    font-weight: 600;
    cursor: pointer;
    display: flex;
    justify-content: space-between;
    align-items: center;
    transition: all 0.3s ease-out;
    user-select: none;
  }
  .category-header.active,
  .category-header:hover {
    background: #e9e5dd;
  }
  .category-header.active {
    border-bottom: 1px solid #000;
  }
  .category-title {
    display: flex;
    align-items: center;
    gap: 12px;
  }
  .category-icon {
    font-size: 1rem;
  }
  .category-icon img {
    width: 35px;
    height: 35px;
    object-fit: contain;
  }
  .category-count {
    background: #e9e5dd;
    padding: 0;
    border-radius: 50%;
    font-size: 0.9rem;
    font-weight: 500;
    color: #0d3320;
    min-width: 45px;
    min-height: 45px;
    display: flex;
    justify-content: center;
    align-items: center;
    transition: all 0.3s ease-out;
    display: none;
  }
  .category-header.active .category-count,
  .category-header:hover .category-count {
    background: #f6f4f0;
  }
  .category-arrow {
    font-size: 1rem;
    transition: transform 0.3s ease;
  }
  .category-header.active .category-arrow {
    transform: rotate(180deg);
  }
  .category-content {
    display: none;
    padding: 0;
    background: #fafbfc;
  }
  .category-content.active {
    display: block;
    animation: slideDown 0.3s ease;
  }
  @keyframes slideDown {
    from {
      opacity: 0;
      max-height: 0;
    }
    to {
      opacity: 1;
      max-height: 5000px;
    }
  }
  .biomarker-list {
    list-style: none;
    margin: 0;
    padding: 10px 20px 20px;
    background: #f6f4f0;
  }
  .biomarker-item {
    padding: 12px 0;
    position: relative;
    border-bottom: 1px solid #e9e5dd;
  }
  .biomarker-item:last-child {
    border-bottom: none;
    padding-bottom: 5px;
  }
  .biomarker-name {
    font-weight: 600;
    font-size: 14px;
    line-height: 22px;
    color: #0d3320;
    display: block;
    cursor: pointer;
  }
  .biomarker-name:hover {
    color: #0078ae;
  }
  .biomarker-name .add-on {
    margin-left: 4px;
    font-size: 10px;
    line-height: 1;
    color: #4080ae;
    background: rgba(64, 128, 174, 0.1);
    padding: 3px 4px 2px;
    border-radius: 4px;
  }
  #biomarkers-popup .content h2 span.add-on {
    position: relative;
    top: -4px;
    margin-left: 5px;
    font-size: 12px;
    line-height: 1;
    color: #4080ae;
    background: rgba(64, 128, 174, 0.1);
    padding: 3px 5px 3px;
    border-radius: 4px;
  }
  .biomarker-name span sup {
    width: 15px;
    display: inline-block;
  }
  .biomarker-name img {
    margin-left: 6px;
    width: 14px;
    height: 14px;
  }
  .biomarker-item.expanded .expand-icon {
    transform: rotate(90deg);
  }
  .biomarker-description {
    display: none;
    color: #0d3320;
    font-size: 12px;
    line-height: 20px;
    margin-top: 10px;
  }
  .biomarker-description ol {
    padding-left: 20px;
    margin-bottom: 0;
  }
  .biomarker-description ol ul {
    padding-left: 15px;
    list-style: lower-roman;
  }
  .biomarker-description ol li {
    color: #0d3320;
    font-size: 12px;
    line-height: 20px;
  }
  .no-results {
    text-align: center;
    padding: 60px 20px;
    color: #999;
    font-size: 1.2rem;
  }
  .expand-all-btn {
    display: none;
    padding: 12px 30px;
    background: #000;
    color: white;
    border: none;
    border-radius: 30px;
    cursor: pointer;
    font-size: 1rem;
    font-weight: 600;
    transition: all 0.3s ease;
  }
  .expand-all-btn:hover {
    background: #4080ae;
    transform: translateY(-2px);
    box-shadow: 0 5px 15px rgba(64, 128, 174, 0.1);
  }
  @media (max-width: 768px) {
    .container {
      padding: 25px;
    }
    h1 {
      font-size: 2rem;
    }
    .subtitle {
      font-size: 1rem;
    }
    .stat-number {
      font-size: 2rem;
    }
    .category-header {
      font-size: 1.1rem;
      padding: 18px 20px;
    }
    .biomarker-list {
      grid-template-columns: 1fr;
    }
    .search-box {
      min-width: 100%;
    }
  }
  .loading {
    text-align: center;
    padding: 40px;
    color: #667eea;
    font-size: 1.2rem;
  }
  #biomarkers-popup {
    display: block;
    position: fixed;
    top: 0;
    right: 0;
    max-width: 650px;
    width: 100%;
    height: 100%;
    overflow-y: auto;
    background: #ede5dc;
    background: linear-gradient(328deg, #ede5dc 0%, #f3efea 56%, #e9eefa 100%);
    z-index: 2001;
    box-shadow: 0 0 10px rgba(0, 0, 0, 0.1);
    transition: all 0.3s ease;
  }
  #biomarkers-popup.hidden {
    right: -650px;
  }
  #biomarkers-overlay {
    position: fixed;
    inset: 0;
    z-index: 2000;
    display: block;
    backdrop-filter: blur(2px) brightness(50%);
  }
  #biomarkers-overlay.hidden {
    display: none;
  }
  #biomarkers-popup .content {
    position: relative;
    width: 100%;
    height: 100%;
    padding: 30px;
    overflow-y: auto;
  }
  #biomarkers-popup .content h2 {
    font-size: 25px;
    font-weight: 600;
    line-height: 30px;
    color: #0d3145;
    margin-bottom: 20px;
  }
  #biomarkers-popup .content p {
    font-size: 14px;
    font-weight: 400;
    line-height: 22px;
    color: #0d3145;
    margin-bottom: 15px;
  }
  #biomarkers-popup .content .closee {
    position: absolute;
    top: 20px;
    right: 20px;
    cursor: pointer;
  }
  #biomarkers-popup .content .closee img {
    width: 30px;
    height: 30px;
    object-fit: contain;
  }
  #biomarkers-popup .content .description ol,
  #biomarkers-popup .content .description ul {
    margin: 0;
    padding: 0;
    margin-left: 15px;
  }
  #biomarkers-popup .content .description ol li,
  #biomarkers-popup .content .description ul li {
    font-size: 14px;
    font-weight: 400;
    line-height: 22px;
    color: #0d3145;
    margin-bottom: 5px;
  }
  .note {
    font-size: 12px;
    font-weight: 400;
    line-height: 20px;
    margin-bottom: 20px;
  }
  .note span {
    margin-right: 2px;
    font-size: 10px;
    line-height: 1;
    font-weight: 600;
    color: #4080ae;
    background: rgba(64, 128, 174, 0.1);
    padding: 3px 4px 2px;
    border-radius: 4px;
  }
  .subcategory-header {
    font-weight: 600;
    font-size: 16px;
    padding: 15px 20px;
    background-color: #e9e5dd;
    border-bottom: 1px solid #ddd;
    border-top: 1px solid #ddd;
  }
  .biomarkars-lists {
  grid-column-gap: 8px;
  grid-row-gap: 8px;
  flex-flow: wrap;
  justify-content: flex-start;
  align-items: flex-start;
  display: flex;
}

.biomarkars-list-link {
  border: 1px solid #0d31454d;
  border-radius: 18px;
  padding: 9px 10px;
  line-height: 18px;
  text-decoration: none;
}

.biomarkars-list-link:hover,
.biomarkars-list-link:focus,
.biomarkars-list-link:active,
#bm-search-clear:hover,
#bm-search-clear:focus,
#bm-search-clear:active {
  text-decoration: none;
}

.paragraph-54 {
  text-align: center;
  margin-bottom: 0;
  font-size: 14px;
  font-weight: 500;
  line-height: 18px;
}

.bio-text-link {
  margin-bottom: 0;
  color: #0d3145!important;
}

.bio-text-link.active-color {
  color: #fff!important;
}
  .biomarkars-list-link.active {
    background: #2d68b5;
  }
  .biomarkars-list-link.active p {
    color: #fff!important;
  }
  
  .search-box a {
    display: block;
    position: absolute;
    right: 15px;
    top: 15px;
    cursor: pointer;
    text-decoration: none;
  }